Etiology of bipolar disorder Research Paper Example | Topics and Well Written Essays - 500 words

Etiology of bipolar disorder - Research Paper Example ological but lately intensive psychotherapy is being increasingly recognized as a better alternative, although absolute therapy is still considered to be in its experimental stages. There have numerous studies to explain the etiology of the disease which have progressed from explanations of behavioral, social and psychological factors as its causes to the imbalance of neurotransmitters in the brain and genetic defects making certain individuals particularly prone to it. As bipolar psychiatric disorder is characterized by sporadic, alternating events of depression and hyper manic state, the excitatory and inhibitory neuronal transmission have been the prime targets of pharmacological interventions. Molecular and cellular targets include inhibition of enzymes such as inositol monophosphatase, inositol polyphosphate 1-phosphatase, etc. by the administration of lithium salts whereby the lithium ion competes for a magnesium binding site which is responsible for prompting the action of such enzymes (Gould et al, 2004). Similarly valproate and carbamazapine inhibit another set of enzymes, as well as molecular signaling pathways in neuronal transmission. Inhibition of these enzymes is responsible for the tentative therapeutic action. Another aspect which has been noticed in psychiatric disease is the high heritability of schizophrenia as well as bipolar disorders which points a finger at the genetic predisposition to such disorders (Owen et al, 2004). Experimental studies in molecular genetics are already underway and chromosomal abnormalities have been noticed at specific locations of the human genome obtained from sufferers of psycho somatic disease. In bipolar disease, involvement of multiple genes has been suspected for long and studies are therefore intricate in design, but feasible with the modern tools of molecular biology which have become available only recently. In a genome wide association study conducted on pooled samples obtained primarily from European

Constitutional law Essay Example | Topics and Well Written Essays - 2000 words - 1

Constitutional law - Essay Example The powers of the government should be controlled in order to ensure that its exercise of such powers does not cause destruction of the values it intended to uphold.4 According to the rule of law, an individual can only be punished in case of breach of the law.5 "Everyone is equal before the law and no one is above the law."6 It is the responsibility of the court to provide a remedy for any breach of an individual right. â€Å"The wider concept of rule of law fits with the idea of a codified constitution articulating a form of ‘higher law;’ or a set of shared community values which the people adopting the constitution wish to promote and protect, and against which they wish all other legislation to be measured.†7 The uncodified UK law does not provide these differences, but it affirms to that the government is subject to the law and so it is under the control of the courts.8 Therefore, the court themselves must be free of government’s influence in order to control the government effectively. In order to avoid concentration of too much power to a single body there should be separation of powers between the three governme nt institutions for effective application of law as established in various constitutions recognizing various government institutions.9 The constitutional theorists have recognized the role of government in the society by expressing their determination to put the government under control and establish a limit on how the government exercises its constitutional powers.10 The doctrine of separation of powers remains the main guiding principle for the proper organization of government.11 However, as suggested by the Montesquieu model of separation of power the theory of separation of powers has not been fully implemented. His model suggests partial separation of persons and functions of various branches of the government.12 The UK constitution has